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Positive airway pressure delivery: overcoming old hurdles, exploring new frontiers (Frontiers in Sleep)

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References
1 Bakker JP, et al. Adherence to CPAP: what should we be aiming for, and how can we get there? Chest. 2019;155(6):1272-1287. doi:10.1016/j.chest.2019.01.012
2 Qiao M, et al. Long-term adherence to continuous positive airway pressure in mild obstructive sleep apnea. BMC Pulmonary Medicine. 2023;23(1):320. doi:10.1186/s12890-023-02612-3
3 White DP, et al. Kairos positive airway pressure (KPAP) equals continuous PAP in effectiveness, and offers superior comfort for obstructive sleep apnea treatment. Sleep Medicine. 2024;124:268-275. doi:10.1016/j.sleep.2024.09.028
*In the Efficacy trial (N=48), PAP-treated OSA patients were administered KPAP and CPAP in random order during a split-night, in-laboratory polysomnography using a blinded crossover design. KPAP demonstrated equivalent efficacy to CPAP in reducing AHI (mean difference [95%CI]: −0.5 [−0.8, −0.2] events/h, P=0.007). Unintentional mask leak was reduced by 40% (−2.0 [−2.5, −1.4] L/min, P<0.001).