Perfecting the science of precise pressure.

Introducing

KPAP™(Kairos Positive Airway Pressure)

For the first time, a radically new pressure algorithm demonstrates improved patient comfort by delivering the optimal inspiratory and expiratory pressure...
at the right time.

Kricket™ and KPAP™: Under 510K review. Not available for sale in the U.S. Any claims associated with KPAP™ have not yet been reviewed by FDA.

Previous efforts to address the condition while making therapy comfortable and tolerable have fallen short.

Normal

Apnea

CPAP Mask

BiPAP

C-FLEX

EPR

  • Lowering IPAP
    makes inspiratory pattern and flow more like a patient’s normal respiration.


  • Lowering EPAP
    reduces expiratory work of breathing.


  • Yet returning pressure to optimal levels when appropriate.

We need to make therapy be more like natural breathing.

Optimizing pressure
delivers a better way.

Timing is everything.

KPAP™

  • Inspiration: Pressure dropped 2cm and then 3cm H2O yielding a pressure 5cm H2O below therapeutic pressure.
  • Expiration: Pressure down at initiation of expiration and stays down through most of the expiratory cycle.
  • End Expiration: Pressure returned to therapeutic levels to assure optimal pharyngeal patency and lung volume.

KPAP™ preferred to CPAP by virtually all patients

KPAP™ Comfort Study Results

  • 150 patients with recently diagnosed, untreated OSA with an AHI>10.
  • Prior to initiation of PAP were exposed to and asked to compare for comfort:
    • CPAP at 9 and 13cm H2O
    • KPAP™ at 9 and 13cm H2O with various pressure drops
  • Outcome:
    • Patient selects each time whether CPAP or KPAP™ is more comfortable in blinded manner

( )-First and second pressure drops with KPAP
*IRB-approved patient consent study

KPAP™ delivers equivalent therapeutic efficacy to standard CPAP

KPAP™ Efficacy Trial

  • 50 patients with documented OSA on stable APAP with >6 hours per night adherence.
  • Reported to the sleep lab for a full night PSG. In random order the patient slept:
    • Half the night on CPAP set at the P95 pressure determined from the PAP device at home.
    • Half the night on KPAP™ set at the same P95 with a 2cm then 3cm H2O (total 5 cm H2O) drop during inspiration and a return to the P95 pressure approximately half way through expiration.
  • Comparisons of CPAP versus XPAP included:
    • AHI 3a (3% fall in Sp02 or arousal to score hypopneas)
    • AHI 4 (4% fall in Sp02 to score hypopneas)
    • AHI in REM and NREM sleep
    • AHI supine and lateral

In conclusion:

  • KPAP™ has the same efficacy in treating OSA as standard CPAP despite dropping the pressure by 5cm H2O.
  • Patients initiating PAP therapy virtually all found KPAP™ more comfortable than CPAP.
  • We now need to conduct adherence trials comparing KPAP™ (with auto-titration) to standard APAP.
    • 6-week randomized crossover trial with adherence as the primary outcome.

Want to learn more?

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Device shown for illustrative purposes only
Kricket™ and KPAP™: Under 510K review. Not available for sale in the U.S. Any claims associated with KPAP™ have not yet been reviewed by FDA.